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MODAFINIL FOR NARCOLEPSY
A sleep-wake dysregulation disease called narcolepsy is characterized by excessive daytime sleepiness.Other REM-sleep abnormalities including cataplexy are frequently linked to it.
The predominant symptom, excessive daytime sleepiness, may manifest as Sleep attacks which arebrief, hard-to-resist lapses into sleep, frequently accompanied by REM sleep. Hallucinations that arehypnagogic or hypnopompic as well as sleep paralysis are other symptoms.
How does modafinil work on narcolepsy?
For many years, amphetamine-like stimulants like methylphenidate (Ritalin) and dextroamphetamine (Dexadrine), which are FDA-approved for this reason, were the mainstays of treatment for narcolepsy.
However, these are controlled compounds listed on Schedule II and have been linked to tachyphylaxis and amphetamine withdrawal syndrome.
The hallmark of narcolepsy is somnolence, which is occasionally accompanied by hallucinations orparalysis before going to sleep or upon awakening, as well as abrupt spells of weakness (cataplexy) when awake. Antidepressants are used to treat cataplexy, whereas napping treatment and CNS stimulants like methylphenidate and d-amphetamine are used to cure somnolence.
The U.S. Food and Drug Administration has approved modafinil, a benzhydryl sulfinyl acetamide non-amphetamine stimulant, for the treatment of excessive daytime drowsiness caused by narcolepsy. Since Buy modafinil online in New York , it has been utilized across Europe. The Medical Letter on Drugs and Therapeutic consultants looked through the modafinil efficacy and safety data.
Modafinil exact mode of action is uncertain, however, research on animals shows that it affects brain regions that control biological clock regulation and sleep/wake cycles. It makes animals more active without making them agitated. Alpha1-adrenergic antagonists lessen its effect on promoting wakefulness. Within two hours, modafinil reaches its peak absorption rate.
Because CYP3A4 is involved in part in the metabolism of modafinil, concurrent use of any 3A4 inducers, substrates, or inhibitors may have an impact on the drug's concentrations and the time it takes to take effect. Additionally, it is a reversible CYP2C19 inhibitor and may raise levels of medications like
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